Pesquisa | BVS IEC

1.

A pairwise cytokine code explains the organism-wide response to sepsis.

Takahama, Michihiro; Patil, Ashwini; Richey, Gabriella; Cipurko, Denis; Johnson, Katherine; Carbonetto, Peter; Plaster, Madison; Pandey, Surya; Cheronis, Katerina; Ueda, Tatsuki; Gruenbaum, Adam; Kawamoto, Tadafumi; Stephens, Matthew; Chevrier, Nicolas.

Nat Immunol ; 25(2): 226-239, 2024 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-38191855

2.

Synergism of TNF-α and IFN-Î³ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes.

Karki, Rajendra; Sharma, Bhesh Raj; Tuladhar, Shraddha; Williams, Evan Peter; Zalduondo, Lillian; Samir, Parimal; Zheng, Min; Sundaram, Balamurugan; Banoth, Balaji; Malireddi, R K Subbarao; Schreiner, Patrick; Neale, Geoffrey; Vogel, Peter; Webby, Richard; Jonsson, Colleen Beth; Kanneganti, Thirumala-Devi.

Cell ; 184(1): 149-168.e17, 2021 01 07.

Artigo em Inglês | MEDLINE | ID: mdl-33278357

3.

Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death.

Taft, Justin; Markson, Michael; Legarda, Diana; Patel, Roosheel; Chan, Mark; Malle, Louise; Richardson, Ashley; Gruber, Conor; Martín-Fernández, Marta; Mancini, Grazia M S; van Laar, Jan A M; van Pelt, Philomine; Buta, Sofija; Wokke, Beatrijs H A; Sabli, Ira K D; Sancho-Shimizu, Vanessa; Chavan, Pallavi Pimpale; Schnappauf, Oskar; Khubchandani, Raju; Cüceoglu, Müserref Kasap; Özen, Seza; Kastner, Daniel L; Ting, Adrian T; Aksentijevich, Ivona; Hollink, Iris H I M; Bogunovic, Dusan.

Cell ; 184(17): 4447-4463.e20, 2021 08 19.

Artigo em Inglês | MEDLINE | ID: mdl-34363755

4.

G-CSF drives autoinflammation in APLAID.

Mulazzani, Elisabeth; Kong, Klara; Aróstegui, Juan I; Ng, Ashley P; Ranathunga, Nishika; Abeysekera, Waruni; Garnham, Alexandra L; Ng, Sze-Ling; Baker, Paul J; Jackson, Jacob T; Lich, John D; Hibbs, Margaret L; Wicks, Ian P; Louis, Cynthia; Masters, Seth L.

Nat Immunol ; 24(5): 814-826, 2023 05.

Artigo em Inglês | MEDLINE | ID: mdl-36997670

5.

Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19.

Kaneko, Naoki; Kuo, Hsiao-Hsuan; Boucau, Julie; Farmer, Jocelyn R; Allard-Chamard, Hugues; Mahajan, Vinay S; Piechocka-Trocha, Alicja; Lefteri, Kristina; Osborn, Matthew; Bals, Julia; Bartsch, Yannic C; Bonheur, Nathalie; Caradonna, Timothy M; Chevalier, Josh; Chowdhury, Fatema; Diefenbach, Thomas J; Einkauf, Kevin; Fallon, Jon; Feldman, Jared; Finn, Kelsey K; Garcia-Broncano, Pilar; Hartana, Ciputra Adijaya; Hauser, Blake M; Jiang, Chenyang; Kaplonek, Paulina; Karpell, Marshall; Koscher, Eric C; Lian, Xiaodong; Liu, Hang; Liu, Jinqing; Ly, Ngoc L; Michell, Ashlin R; Rassadkina, Yelizaveta; Seiger, Kyra; Sessa, Libera; Shin, Sally; Singh, Nishant; Sun, Weiwei; Sun, Xiaoming; Ticheli, Hannah J; Waring, Michael T; Zhu, Alex L; Alter, Galit; Li, Jonathan Z; Lingwood, Daniel; Schmidt, Aaron G; Lichterfeld, Mathias; Walker, Bruce D; Yu, Xu G; Padera, Robert F.

Cell ; 183(1): 143-157.e13, 2020 10 01.

Artigo em Inglês | MEDLINE | ID: mdl-32877699

6.

Coupled scRNA-Seq and Intracellular Protein Activity Reveal an Immunosuppressive Role of TREM2 in Cancer.

Katzenelenbogen, Yonatan; Sheban, Fadi; Yalin, Adam; Yofe, Ido; Svetlichnyy, Dmitry; Jaitin, Diego Adhemar; Bornstein, Chamutal; Moshe, Adi; Keren-Shaul, Hadas; Cohen, Merav; Wang, Shuang-Yin; Li, Baoguo; David, Eyal; Salame, Tomer-Meir; Weiner, Assaf; Amit, Ido.

Cell ; 182(4): 872-885.e19, 2020 08 20.

Artigo em Inglês | MEDLINE | ID: mdl-32783915

7.

Group 3 innate lymphoid cells produce the growth factor HB-EGF to protect the intestine from TNF-mediated inflammation.

Zhou, Lei; Zhou, Wenqing; Joseph, Ann M; Chu, Coco; Putzel, Gregory G; Fang, Beibei; Teng, Fei; Lyu, Mengze; Yano, Hiroshi; Andreasson, Katrin I; Mekada, Eisuke; Eberl, Gerard; Sonnenberg, Gregory F.

Nat Immunol ; 23(2): 251-261, 2022 02.

Artigo em Inglês | MEDLINE | ID: mdl-35102343

8.

Single-Cell Analysis of Crohn's Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy.

Martin, Jerome C; Chang, Christie; Boschetti, Gilles; Ungaro, Ryan; Giri, Mamta; Grout, John A; Gettler, Kyle; Chuang, Ling-Shiang; Nayar, Shikha; Greenstein, Alexander J; Dubinsky, Marla; Walker, Laura; Leader, Andrew; Fine, Jay S; Whitehurst, Charles E; Mbow, M Lamine; Kugathasan, Subra; Denson, Lee A; Hyams, Jeffrey S; Friedman, Joshua R; Desai, Prerak T; Ko, Huaibin M; Laface, Ilaria; Akturk, Guray; Schadt, Eric E; Salmon, Helene; Gnjatic, Sacha; Rahman, Adeeb H; Merad, Miriam; Cho, Judy H; Kenigsberg, Ephraim.

Cell ; 178(6): 1493-1508.e20, 2019 09 05.

Artigo em Inglês | MEDLINE | ID: mdl-31474370

9.

Cutaneous TRPV1⁺ Neurons Trigger Protective Innate Type 17 Anticipatory Immunity.

Cohen, Jonathan A; Edwards, Tara N; Liu, Andrew W; Hirai, Toshiro; Jones, Marsha Ritter; Wu, Jianing; Li, Yao; Zhang, Shiqun; Ho, Jonhan; Davis, Brian M; Albers, Kathryn M; Kaplan, Daniel H.

Cell ; 178(4): 919-932.e14, 2019 08 08.

Artigo em Inglês | MEDLINE | ID: mdl-31353219

10.

Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold.

Vredevoogd, David W; Kuilman, Thomas; Ligtenberg, Maarten A; Boshuizen, Julia; Stecker, Kelly E; de Bruijn, Beaunelle; Krijgsman, Oscar; Huang, Xinyao; Kenski, Juliana C N; Lacroix, Ruben; Mezzadra, Riccardo; Gomez-Eerland, Raquel; Yildiz, Mete; Dagidir, Ilknur; Apriamashvili, Georgi; Zandhuis, Nordin; van der Noort, Vincent; Visser, Nils L; Blank, Christian U; Altelaar, Maarten; Schumacher, Ton N; Peeper, Daniel S.

Cell ; 178(3): 585-599.e15, 2019 07 25.

Artigo em Inglês | MEDLINE | ID: mdl-31303383

11.

Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis.

Smillie, Christopher S; Biton, Moshe; Ordovas-Montanes, Jose; Sullivan, Keri M; Burgin, Grace; Graham, Daniel B; Herbst, Rebecca H; Rogel, Noga; Slyper, Michal; Waldman, Julia; Sud, Malika; Andrews, Elizabeth; Velonias, Gabriella; Haber, Adam L; Jagadeesh, Karthik; Vickovic, Sanja; Yao, Junmei; Stevens, Christine; Dionne, Danielle; Nguyen, Lan T; Villani, Alexandra-Chloé; Hofree, Matan; Creasey, Elizabeth A; Huang, Hailiang; Rozenblatt-Rosen, Orit; Garber, John J; Khalili, Hamed; Desch, A Nicole; Daly, Mark J; Ananthakrishnan, Ashwin N; Shalek, Alex K; Xavier, Ramnik J; Regev, Aviv.

Cell ; 178(3): 714-730.e22, 2019 07 25.

Artigo em Inglês | MEDLINE | ID: mdl-31348891

12.

TNF Induces Pathogenic Programmed Macrophage Necrosis in Tuberculosis through a Mitochondrial-Lysosomal-Endoplasmic Reticulum Circuit.

Roca, Francisco J; Whitworth, Laura J; Redmond, Sarah; Jones, Ana A; Ramakrishnan, Lalita.

Cell ; 178(6): 1344-1361.e11, 2019 09 05.

Artigo em Inglês | MEDLINE | ID: mdl-31474371

13.

GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance.

Luan, Harding H; Wang, Andrew; Hilliard, Brandon K; Carvalho, Fernando; Rosen, Connor E; Ahasic, Amy M; Herzog, Erica L; Kang, Insoo; Pisani, Margaret A; Yu, Shuang; Zhang, Cuiling; Ring, Aaron M; Young, Lawrence H; Medzhitov, Ruslan.

Cell ; 178(5): 1231-1244.e11, 2019 08 22.

Artigo em Inglês | MEDLINE | ID: mdl-31402172

14.

Urban living in healthy Tanzanians is associated with an inflammatory status driven by dietary and metabolic changes.

Temba, Godfrey S; Kullaya, Vesla; Pecht, Tal; Mmbaga, Blandina T; Aschenbrenner, Anna C; Ulas, Thomas; Kibiki, Gibson; Lyamuya, Furaha; Boahen, Collins K; Kumar, Vinod; Joosten, Leo A B; Schultze, Joachim L; van der Ven, Andre J; Netea, Mihai G; de Mast, Quirijn.

Nat Immunol ; 22(3): 287-300, 2021 03.

Artigo em Inglês | MEDLINE | ID: mdl-33574617

15.

Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation.

Wu, Bowen; Zhao, Tuantuan V; Jin, Ke; Hu, Zhaolan; Abdel, Matthew P; Warrington, Ken J; Goronzy, Jörg J; Weyand, Cornelia M.

Nat Immunol ; 22(12): 1551-1562, 2021 12.

Artigo em Inglês | MEDLINE | ID: mdl-34811544

16.

Proinflammatory IgG Fc structures in patients with severe COVID-19.

Chakraborty, Saborni; Gonzalez, Joseph; Edwards, Karlie; Mallajosyula, Vamsee; Buzzanco, Anthony S; Sherwood, Robert; Buffone, Cindy; Kathale, Nimish; Providenza, Susan; Xie, Markus M; Andrews, Jason R; Blish, Catherine A; Singh, Upinder; Dugan, Haley; Wilson, Patrick C; Pham, Tho D; Boyd, Scott D; Nadeau, Kari C; Pinsky, Benjamin A; Zhang, Sheng; Memoli, Matthew J; Taubenberger, Jeffery K; Morales, Tasha; Schapiro, Jeffrey M; Tan, Gene S; Jagannathan, Prasanna; Wang, Taia T.

Nat Immunol ; 22(1): 67-73, 2021 01.

Artigo em Inglês | MEDLINE | ID: mdl-33169014

17.

Better Together: A Hybrid Amyloid Signals Necroptosis.

Li, Dan; Liu, Cong.

Cell ; 173(5): 1068-1070, 2018 05 17.

Artigo em Inglês | MEDLINE | ID: mdl-29775589

18.

Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture.

Peng, Weng Chuan; Logan, Catriona Y; Fish, Matt; Anbarchian, Teni; Aguisanda, Francis; Álvarez-Varela, Adrián; Wu, Peng; Jin, Yinhua; Zhu, Junjie; Li, Bin; Grompe, Markus; Wang, Bruce; Nusse, Roel.

Cell ; 175(6): 1607-1619.e15, 2018 11 29.

Artigo em Inglês | MEDLINE | ID: mdl-30500539

19.

Natural Killer Cells Control Tumor Growth by Sensing a Growth Factor.

Barrow, Alexander D; Edeling, Melissa A; Trifonov, Vladimir; Luo, Jingqin; Goyal, Piyush; Bohl, Benjamin; Bando, Jennifer K; Kim, Albert H; Walker, John; Andahazy, Mary; Bugatti, Mattia; Melocchi, Laura; Vermi, William; Fremont, Daved H; Cox, Sarah; Cella, Marina; Schmedt, Christian; Colonna, Marco.

Cell ; 172(3): 534-548.e19, 2018 01 25.

Artigo em Inglês | MEDLINE | ID: mdl-29275861

20.

TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging.

Xu, Daichao; Jin, Taijie; Zhu, Hong; Chen, Hongbo; Ofengeim, Dimitry; Zou, Chengyu; Mifflin, Lauren; Pan, Lifeng; Amin, Palak; Li, Wanjin; Shan, Bing; Naito, Masanori Gomi; Meng, Huyan; Li, Ying; Pan, Heling; Aron, Liviu; Adiconis, Xian; Levin, Joshua Z; Yankner, Bruce A; Yuan, Junying.

Cell ; 174(6): 1477-1491.e19, 2018 09 06.

Artigo em Inglês | MEDLINE | ID: mdl-30146158

BVS IEC

Instituto Evandro Chagas

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